The test group received aqueous Azadirachta indica leaf extract orally at a dose level of 300 mg/kg body weight three times a week for 20 weeks. The results of this study revealed the chemopreventive potential of A. In another study, the antifungal activity of aqueous extracts prepared from A. cepa (onion; AOE) and Allium sativum (garlic; AGE) were evaluated against Malassezia furfur , Candida albicans , other Candida sp.
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The results revealed that leaf extract and the non-alkaloid fraction are valuable antitumor promotors in carcinogenesis. Wrinkles, rosacea, spider veins and varicose veins are among those conditions that cannot be neatly categorized. Wrinkles are caused by a breakdown of the collagen and elastin within the dermis, which results in sagging skin. Rosacea is a chronic disorder in which the skin of the face becomes red and develops pimples, lesions and more rarely enlargement of the nose.
Spider veins and varicose veins become apparent when blood vessels enlarge and become visible through the surface of the skin. Trauma describes an injury to the skin caused by a blow, a cut, or a burn. Whenever the surface of the skin is broken, the body becomes more susceptible to infection and disease. The amount of pigment in the skin is determined by the amount of melanin being produced by the body.
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One of the experiments carried out in 34 patients with venous leg ulcers to determine the therapeutic efficacy of ME on the epithelialization of lower leg venous ulcers revealed significant acceleration of wound healing by producing epithelialization. Research conducted on cream preparations containing seven different types of marigold and rosemary extracts, revealed that such creams are effective in experimentally induced irritant contact dermatitis when tested on healthy human volunteers. The flowers of marigold have long been employed in folk therapy and more than 35 properties have been attributed to decoctions and tinctures from the flowers. The main uses are as remedies for burns , bruises and cutaneous and internal inflammatory diseases of several origins. Skin tumors obtained in the DMBA/TPA group exhibited enhanced expression of proliferating cell nuclear antigen , p21 and cyclin D1, with no alterations in p53 expression in comparison to the control group.
purpurea completely reversed this effect and brought the cytokine levels back to normal. Thus Echinaforce® could provide a safe two-fold benefit to acne individuals by inhibiting proliferation of the organism and reversing the bacterial-induced inflammation. Echinacea has been applied to and used to treat skin problems such as skin boils, wounds, ulcers, burns, herpes, hemorrhoids and psoriasis.
The results indicated that onion and garlic might be promising in treatment of fungal-associated diseases from important pathogenic genera like Candida, Malassezia and the dermatophytes. Traditionally, the plant is used in boils, scabies and eruptions of skin and other skin diseases. The MeOH extract, alkaloid, non-alkaloid and saponin fractions obtained from the leaves of A. aspera exhibited significant inhibitory effects (concentration 100 μg) on the Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promotor 12-O-tetradecanoylphorbol-13-acetate in Raji cells.
Tumors in AAILE + DMBA/TPA group exhibited low PCNA and cyclin D1 expression and enhanced expression of p53 and p21 in comparison to the DMBA/TPA group. The skin tumors obtained in the AAILE + DMBA/TPA group exhibited high lipid peroxidation levels in comparison to the tumors obtained in the DMBA/TPA group. The observations of the study suggested that AAILE behaves as a pro-oxidant in the tumors, thereby rendering them susceptible to damage, which eventually culminates into its anti-neoplastic action. Also, cell cycle regulatory proteins may be modulated by AAILE and could affect the progression of cells through the cell cycle. In one study, skin tumors were induced in mice by topical application of DMBA (500 nmol/100 μl for 2 weeks) followed by TPA (1.7 nmol/100 μl of acetone, twice weekly) as a promoter.
In this in vitro assay the non-alkaloid fraction containing mainly non-polar compounds showed the most significant inhibitory activity (96.9%; 60% viability). In the in vivo two-stage mouse skin carcinogenesis test the total methanolic extract possessed a pronounced ant carcinogenic effect (76%).